Best chemotherapy adjuvant for ovarian cancer.  | 1+1> 487%  

Effectively improve chemotherapy effect, treatment, immunity.  

Reduce side effects and recurrence.  

Combination Therapy | Overview / Relationship / Abstract / Role / Principle / Action / Mechanism / Function / Work.

Solamargine vs Ovarian cancer

Abstract / Summary / Overview of ovarian Cancer.

Abstract / Summary / Overview of Apoptosis.

Role, Principle, Action, Mechanism, Function, Work of Solamargine.

Best chemotherapy aid for ovarian cancer.  | 1 + 1> 487% 

Effectively improve chemotherapy effect, treatment and immunity.

Solanum Incanum Extract Downregulates Aldehyde Dehydrogenase 1-Mediated Stemness and Inhibits Tumor Formation in Ovarian Cancer Cells.

Abstract / Summary / Overview of Ovarian Cancer. 

Among gynecological cancers, ovarian carcinoma has the highest mortality rate, and chemoresistance is highly prevalent in this cancer.

Epithelial ovarian carcinoma (EOC) is the most lethal gynecological malignancy.

The initial symptoms are vague, and the majority of women have advanced disease at the time of diagnosis. 

The standard treatment is aggressive cytoreductive surgery, followed by platinum-taxane based chemotherapy. 

After therapy, a significant number of patients eventually relapse and develop chemoresistance, leading to a very low overall survival rate. 

Despite the incorporation of new chemotherapies for EOC treatment, only a small increase in overall survival has been achieved. 

Additionally, second-line chemotherapeutics can cause substantial adverse effects in patients. 

This highlights a need for novel therapeutic approaches to improve EOC treatment.

Although recent advances in the understanding of the biological characteristics of this illness and multidisciplinary therapeutic approaches, such as individuated chemotherapy, targeted therapies, immune approaches, and improved supportive care, the outcome remains dismal for patients with advanced disease.

One approach to overcome this problem is the development of new agents that can be used in combination with existing chemotherapeutics to yield better results than chemotherapeutics alone. 

Therefore, searching for more effective alternative treatment strategies in order to strengthen the therapeutic efficacy with negligible side effects is urgently needed.

Accumulating evidence suggests that many natural products, including extracts and isolated chemicals, have the potential to interact with multiple targets in the signaling pathways that regulate cancer progression. 

Natural phytochemicals derived from medicinal plants have gained significant recognition in the control of carcinogenesis and are considered as a novel approach in the prevention and treatment of cancer.

A large number of investigators have now reported that Solamargine induces cell cycle arrest and apoptosis in a wide variety of cancer cells, such as ovarian cancer, basal cell carcinoma, squamous cell carcinoma, melanoma, colorectal cancer, bladder cancer, oral epidermoid carcinoma, breast cancer, myelogenous leukemia, prostate cancer, liver cancer, lung cancer, endometrial cancer, pancreatic cancer, gastric carcinoma, renal cancer, uterine cancer, mesothelioma, glioblastoma, and osteosarcoma.

Abstract / Summary / Overview of Apoptosis. 

•Programmed cell death.

•Apoptosis is a form of programmed cell death, or “cellular suicide.”

•Apoptosis is different from necrosis, in which cells die due to injury.

•Apoptosis removes cells during development, eliminates potentially cancerous and virus-infected cells, and maintains balance in the body.

Why do cells undergo apoptosis? 

Basically, apoptosis is a general and convenient way to remove cells that should no longer be part of the organism.

Some cells are abnormal and could hurt the rest of the organism if they survive, such as cells with viral infections or DNA damage.

Apoptosis is part of development.

In many organisms, programmed cell death is a normal part of development.

The relationship between cancer cells and apoptosis. 

Apoptosis can eliminate infected or cancerous cells.

When a cell’s DNA is damaged, it will typically detect the damage and try to repair it. 

If the damage is beyond repair, the cell will normally send itself into apoptosis, ensuring that it will not pass on its damaged DNA. 

When cells have DNA damage but fail to undergo apoptosis, they may be on the road to cancer.

However, “successful” cancer cells successfully evade the process of apoptosis.

This allows them to divide out of control and accumulate mutations (changes in their DNA).

Apoptosis is key to immune function.

Apoptosis also plays an essential role in the development and maintenance of a healthy immune system. 

Where are the weaknesses and symptoms of cancer cells? 

The symptoms of cancer cells are in the nucleus.

The nucleus controls the outer cytoplasm, cell composition, cell viability, etc.

DNA mutations also mutate in the nucleus.

Therefore, to treat cancer cells, we must first enter the nucleus.

Let the “regulatory cell gene” mechanism enter the nucleus to regulate

Are cancer cells aggressive?

After the action of Solamargine, the aggressiveness of cancer cells is alleviated.

So after using Solamargine, many patients feel that I am half better.

Although the tumor does not disappear quickly, patients feel that the degree of aggressiveness is reduced.

Role, Principle, Action, Mechanism, Function, Work of Solamargine.

Solamargine major function mechanism, role, principle, action, function, work :

When Solamargine enter,

Solamargine activates receptors that are turned off by cancer cells, allowing cancer cells to modulate again.

Solamargine modulates the anti-modulates genes of cancer cells, making cancer cells less resistant.

Reduced drug resistance.

When cancer cells are less resistant to drugs, chemotherapy becomes more effective.

Solamargine modulates the mutated genes in cancer cells and then initiates cancer cell apoptosis to achieve anti-cancer effects.

More specifically, it was shown the Solamargine, in particular, induced apoptosis (target) in cancer cells but not normal cells. 

Solamargine combined with which chemotherapy drugs are more effective in treating cancer cells? 

A: Cisplatin (CDDP) , Cranberry, Methotrexate, 5-Fu.

Best chemotherapy adjuvant for ovarian cancer. | 1 + 1> 487%  

Effectively improve chemotherapy effect, treatment,  immunity.

Reduce side effects and recurrence.  

Combination Therapy |  Overview / Relationship / Abstract / Role / Principle / Action / Mechanism / Function / Work

ANTI-CANCER 

Patent protection in 32 nations. 

A comparison study showing Solamargine vs. other therapeutic drugs with respect to lung cancer cells.

Solamargine, the typical metabolites of solanum lycocarpum fruit glycoalkaloid extract from traditional herbal medicine, demonstrated not only anti-viral, anti-inflammatory but also antiproliferative activity against the multiple types of human cancers including ovarian.

Solamargine, isolated from Solanum incanum herb, displayed a superior cytotoxicity in four human lung cancer cell lines. 

Solamargine not only inhibits cell growth of lung cancer, SCLC, NSCLC, ovarian cancer, liver cancer, Melanoma, Ovarian cancer and Cholangiocarcinoma but also enhances the cytotoxicity of chemotherapy agents such as cisplatin, doxorubicin and docetaxel.

The picture shows the death of cancer cells.

The black and black parts are cancer cell nuclei.

Even if the nucleus ruptures, the cancer cells will die.

The figure shows that cancer cells can cause death.

The figure shows that cancer cells can cause death.

The figure shows that the death of lung cancer cells is relatively slow, and it will not be obvious until eight hours later.

The figure shows that the death of liver cancer cells is very obvious, even more obvious in eight hours.

The graph shows that breast cancer cells die faster. It was obvious from the beginning that breast cancer is easy to treat, and patients with ovarian cancer need not worry.

Solanum Incanum Extract Downregulates Aldehyde Dehydrogenase 1-Mediated Stemness and Inhibits Tumor Formation in Ovarian Cancer Cells.

In study, Solamargine induces apoptosis of the ovarian cancer cells and the mechanism was characterized.

Solamargine(SR-T100) increased cisplatin and paclitaxel sensitivity in chemoresistant cells. 

Solamargine(SR-T100) downregulated the expression of stem cell markers, including aldehyde dehydrogenase 1 (ALDH1), Notch1, and FoxM1, and reduced sphere formation in ovarian cancer cells.

Results

Solamargine (SR-T100) sensitizes chemoresistant cells to cisplatin and paclitaxel

Furthermore, combination treatment using cisplatin and SR-T100 was more effective in inhibiting the growth of A2780CP70 cells in mouse xenografts than either therapeutic alone.

The combined use of Solamargine(SR-T100) and CDDP is effective in CDDP-resistant ovarian cancer.

Combination Therapy | Research results for lung cancer cells. 

A. Cisplatin (100μM), 16% of cancer cell apoptosis. 

B. Alone SM (4.8μM), 28% of cancer cell apoptosis. 

C. SM (4.80μM) + Cisplatin (40μM), 66% of cancer cells apoptosis. 

D. SM (4.80μM) + Cisplatin (100μM), 78% of cancer cell apoptosis.

Solamargine has a clearing effect better than Cisplatin.

The combined treatment of Solamargine and Cisplatin significantly increased the apoptosis of lung cancer cells. 

SM (4.8μM) + Cisplatin (40μM), increased from 16% to 66% (up to 4.125 times). 

SM (4.8μM) + Cisplatin (100μM), increased from 16% to 78% (up to 4.875 times). 

Reorganized from: BBRC. Action of Solamargine on TNFs and drug-resistant human lung cancer cells 2004.

Excerpted from: https://www.ncbi.nlm.nih.gov/