Best chemotherapy adjuvant for breast cancer | 1+1> 487%
Effectively improve chemotherapy effect, treatment and immunity | Reduce side effects and recurrence
Combination Therapy | Overview/Relationship/Abstract/Role/Principle/Action/Mechanism/Function/Work
Abstract / Summary / Overview of breast Cancer
Abstract / Summary / Overview of Apoptosis
Role, Principle, Action, Mechanism, Function, Work of Solamargine
Best chemotherapy aid for breast cancer | 1 + 1> 487% | Effectively improve chemotherapy effect, treatment and immunity
Downregulation of HER2/neu receptor by Solamargine enhances anticancer drug-mediated cytotoxicity in breast cancer cells with high-expressing HER2/neu
Solamargine induces apoptosis and enhances susceptibility to trastuzumab and epirubicin in breast cancer cells with low or high expression levels of HER2/neu
Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin.
Best chemotherapy adjuvant for breast cancer | 1+1> 487%
Effectively improve chemotherapy effect, treatment and immunity | Reduce side effects and recurrence
Combination Therapy | Overview/Relationship/Abstract/Role/Principle/Action/Mechanism/Function/Work
Abstract / Summary / Overview of Breast Cancer
Breast cancer is the most prevalent cancer in women worldwide
Although recent advances in understanding of the biological characteristics of this illness and multidisciplinary therapeutic approaches, such as individuated chemotherapy, targeted therapies, immune approaches and improved supportive care, the outcome remains dismal for patients with advanced disease.
The 5-year survival rate for stage IV breast cancer is only 22% (https://www.cancer.ca/en/cancer-information/cancer-type/breast/prognosis-and-survival/survival-statistics/?region=on).
Therefore, searching for more effective alternative treatment strategies in order to strengthen the therapeutic efficacy with negligible side effects is urgently needed.
Natural phytochemicals derived from medicinal plants have gained significant recognition in the control of carcinogenesis and are considered as a novel approach in the prevention and treatment of cancer.
Abstract / Summary / Overview of Apoptosis
•Programmed cell death
•Apoptosis is a form of programmed cell death, or “cellular suicide.”
•Apoptosis is different from necrosis, in which cells die due to injury.
•Apoptosis removes cells during development, eliminates potentially cancerous and virus-infected cells, and maintains balance in the body.
Why do cells undergo apoptosis?
Basically, apoptosis is a general and convenient way to remove cells that should no longer be part of the organism.
Some cells are abnormal and could hurt the rest of the organism if they survive, such as cells with viral infections or DNA damage.
Apoptosis is part of development.
In many organisms, programmed cell death is a normal part of development.
The relationship between cancer cells and apoptosis.
Apoptosis can eliminate infected or cancerous cells.
When a cell’s DNA is damaged, it will typically detect the damage and try to repair it.
If the damage is beyond repair, the cell will normally send itself into apoptosis, ensuring that it will not pass on its damaged DNA.
When cells have DNA damage but fail to undergo apoptosis, they may be on the road to cancer.
However, “successful” cancer cells successfully evade the process of apoptosis.
This allows them to divide out of control and accumulate mutations (changes in their DNA).
Apoptosis is key to immune function.
Apoptosis also plays an essential role in the development and maintenance of a healthy immune system.
Where are the weaknesses and symptoms of cancer cells?
The symptoms of cancer cells are in the nucleus.
The nucleus controls the outer cytoplasm, cell composition, cell viability, etc.
DNA mutations also mutate in the nucleus.
Therefore, to treat cancer cells, we must first enter the nucleus.
Let the “regulatory cell gene” mechanism enter the nucleus to regulate.
Are cancer cells aggressive?
After the action of Solamargine, the aggressiveness of cancer cells is alleviated.
So after using Solamargine, many patients feel that I am half better.
Although the tumor does not disappear quickly, patients feel that the degree of aggressiveness is reduced.
Role, Principle, Action, Mechanism, Function, Work of Solamargine
Solamargine's major function mechanism, principle, action, function, work :
When Solamargine enter,
Solamargine activates receptors that are turned off by cancer cells, allowing cancer cells to modulate again.
Solamargine modulates the anti-modulates genes of cancer cells, making cancer cells less resistant.
Reduced drug resistance.
When cancer cells are less resistant to drugs, chemotherapy becomes more effective.
Solamargine modulates the mutated genes in cancer cells and then initiates cancer cell apoptosis to achieve anti-cancer effects.
Solamargine combined with which chemotherapy drugs are more effective in treating cancer cells?
A: Cisplatin (CDDP) , Cranberry, Methotrexate, 5-Fu.
Best chemotherapy adjuvant for breast cancer | 1 + 1> 487%
Effectively improve chemotherapy effect, treatment and immunity | Reduce side effects and recurrence
Combination Therapy | Overview/Relationship/Abstract/Role/Principle/Action/Mechanism/Function/Work
Solamargine vs cancer
ANTI-CANCER
Patent protection in 32 nations.
A comparison study showing SM vs. other therapeutic drugs with respect to lung cancer cells.
Solamargine (SM), the typical metabolites of solanum lycocarpum fruit glycoalkaloid extract from traditional herbal medicine, demonstrated not only anti-viral, anti-inflammatory but also antiproliferative activity against the multiple types of human cancers including breast.
Solamargine (SM), isolated from Solanum incanum herb, displayed a superior cytotoxicity in four human lung cancer cell lines.
Solamargine not only inhibits cell growth of lung cancer, SCLC, NSCLC, breast cancer, liver cancer, Melanoma, Ovarian cancer and Cholangiocarcinoma but also enhances the cytotoxicity of chemotherapy agents such as cisplatin, doxorubicin and docetaxel.
The picture shows the death of cancer cells.
The black and black parts are cancer cell nuclei.
Even if the nucleus ruptures, the cancer cells will die.
The graph shows that whether it is liver cancer, lung cancer, or breast cancer will cause death.
The graph shows that whether it is liver cancer, lung cancer, or breast cancer will cause death.
The figure shows that the death of lung cancer cells is relatively slow, and it will not be obvious until eight hours later.
The figure shows that the death of liver cancer cells is very obvious, even more obvious in eight hours.
The graph shows that breast cancer cells die faster. It was obvious from the beginning that breast cancer is easy to treat, and patients with breast cancer need not worry.
3. Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin
In study, SM induces apoptosis of the breast cancer cells and the mechanism was characterized.
The combined treatment of SM and CDDP significantly reduced Bcl-2 and Bcl-xL expressions, and enhanced Bax, cytochrome c, caspase-9 and -3 expressions in breast cancer cells.
The combined use of SM and CDDP effective in CDDP-resistant breast cancer.
Combination Therapy | Research results for lung cancer cells.
A. Cisplatin (100μM), 16% of cancer cell apoptosis.
B. Alone Solamargine (4.8μM), 28% of cancer cell apoptosis.
C. Solamargine (4.80μM) + Cisplatin (40pμM), 66% of cancer cells apoptosis.
D. Solamargine (4.80μM) + Cisplatin (100μM), 78% of cancer cell apoptosis.
Solamargine has a clearing effect better than Cisplatin.
The combined treatment of Solamargine and Cisplatin significantly increased the apoptosis of lung cancer cells.
Solamargine (4.8μM) + Cisplatin (40μM), increased from 16% to 66% (up to 4.125 times).
Solamargine (4.8μM) + Cisplatin (100μM), increased from 16% to 78% (up to 4.875 times)
Reorganized from: BBRC. Action of Solamargine on TNFs and drug-resistant human lung cancer cells 2004
All excerpted from: https://www.ncbi.nlm.nih.gov/
