皮膚生理研究
Chin-Han Wu., Chia-Hua Liang., Li-Yen Shiu ., Li-Ching Chang., Tsai-Shiuan Lin （2011） Solanum incanum extract （SR-T100） induces human cutaneous squamous cell carcinoma apoptosis through modulating tumor necrosis factor receptor signaling pathway J. Dermatol. 63, 83-92.
Sheu, H.M., Lee, Y.Y., Kuo, K.W.* and Tsai, J.C. （1998） Permeability Barrier Abnormality of Hairless Mouse Epidermis after Topical Corticosteroid： Characterization of Stratum Corneum Lipids by Ruthenium Tetroxide Staining and High-Performance Thin-Layer Chromatography. J. Dermatol. 25, 281-289.
Sheu, H.M., Lee, Y.Y., Chai, C.Y. and Kuo, K.W. （1997） Depletion of Stratum Corneum Intercellular Lipid Lamellae and Barrier Function Abnomalities after long-Term Topical Corticosteroids. Br. J. Dermatol. 136, 884-890.
Sheu, H.M., Tai, C.L., Kuo, K.W., Yu, H.S. and Chai, C.Y. （1991） Modultion of Epidermal Terminal Differentiation in Patients after Long-term Topical Corticosteroids. J. Dermatol.18, 454-464.
Kuo, K.W.*, Sheu, H.M., Yu, H.S., Shen, T.C. and Chang, C.C. （1990） A Study of Changes in the Ratio of Collagen Types in Skin after Long-Term Treatment with Topical Glucocorticoids. Kaohsiung J. Med. Sci. 6, 224-230.
癌症相關論文
Shiu, L.Y., Liang, C.H., Chang, L.C., Sheu, H.M., Tsai, E.M. and Kuo, K.W.* （2009） Solamargine induces apoptosis and enhances susceptibilities to trastuzumab and epirubicin in breast cancer cells with low-or high-expressing HER2/neu. Bioscience Reports 29, 35-45.
Shiu, L.Y., Liang, C.H., Huang, Y.S., Sheu, H.M. and Kuo, K.W.* （2008） Down-Regulation of HER2/neu Receptor by Solamargine Enhances Anticancer Drug-mediated Cytotoxicity in Breast Cancer Cells with High-expressing HER2/neu. Cell Biology and Toxicology 24, 1-10.
Liang, C.H., Shiu, L.Y., Chang, L.C., Sheu, H.M. and Kuo, K.W.* （2007） Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer cells to trastuzumab and epirubicin. Chemical Research in Toxicology 21, 393-399.
Liang, C.H., Shiu, L.Y., Chang, L.C., Sheu, H.M. and Kuo, K.W.* （2007） Solamargine upregulation of Fas, downregulation of HER2 and enhancement of cytotoxicity using epirubicin in NSCLC cells. Molecular Nutrition and Food Research 51,999-1005.
Shiu, L.Y., Liang, C.H., Huang, Y.S., Sheu, H.M. and Kuo, K.W.* （2007） Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin. Food and Chemical Toxicology 45, 2155-2164.
Liu, L.F., Liang, C.H., Shiu, L.Y., Lin, W.L., Lin, C.C. and Kuo, K.W.* （2004） Action of Solamargine on Human Lung Cancer Cells - Enhancement of the Susceptibility of Cancer cells to TNFS. FEBS Lett. 577,67-74.
Liang, C.H., Liu, L.F., Shiu, L.Y., Huang, Y.S., Chang, L.C. and Kuo, K.W. （2004） Action of Solamargine on TNFs and Cisplatin-resistant Human Lung Cancer Cells. Biochem. Biophys. Res. Commun. 322, 751-758.
Kuo, K.W.*, Hsu, S.H., Li, Y.P., Lin, W.L., Liu, L.F., Chang, L.C., Lin, C.C., Lin, C.N. and Sheu, H.M. （2000） Anticancer Activity Evaluation of the Solanum Glycoalkaloid Solamargine. Triggering Apoptosis in Human Hepatoma Cells. Biochem. Pharmacol. 60, 1865-1873.
Chang, L.C., Sheu, H.M., Huang, Y.S. and Kuo, K.W.* （2000） Quantitative Determination of the Expression of Xeroderma Pigmentosum F（XPF） Gene in Human Nonmelanoma Skin Cancers. Biochem. Biophys. Res. Commun. 273, 454-458.
Chang, L.C., Sheu, H.M., Huang, Y.S., Tsai, T.R. and Kuo, K.W. （1999） A Novel Function of Emodin - Enhancement of the Nucleotide Excision Repair of UV and Cisplatininduced DNA Damage in Human Fibroblast Cells. Biochem. Pharmacol. 58, 49-57.
Kuo, K.W.*, Sheu, H.M., Huang, Y.S. and Leung W.C. （1998） Expression of Transposon LINE-1 is Relatively Human-Specific and Function of the Transcript May be Proliferationessential. Biochem. Biophys. Res. Commun. 253, 566-570.
Huang, C.N., Tsai, Z.N., Wu, W.J., Kuo, K.W. and Huang, C.H. （1998） Changes of the Activities of Mitochondrial Enzymes in the Progress of Tumorigenesis of Bladder Cancer. Biochem. Mol. Biol. Int. 46, 375-383.
Gan, K.H., Fann, Y.F., Hsu, S.H., Kuo, K.W. and Lin, C.N. （1998） Mediation of the Cytotoxicity of Lanostanoids and Steroids of Ganoderma tsugae through Apoptosis and Cell cycle. J. Nat. Prod. 61, 485-487.
Kuo, K.W.*, Yang, P.Y., Huang, Y.S. and Shieh, D.Z. （1998） Variations of the Gene Expression and Genomic Stability of Human Hepatoma Cells Integrated by Hepatitis B Virus DNA. Biochem. Mol. Biol. Int. 44, 1133-1140.
Gan, K.H., Fann, Y.F., Hsu, S.H., Kuo, K.W. and Lin, C.N. （1998） Mediation of the Cytotoxicity of Lanostanoids and Steroids of Ganoderma tsugae through Apoptosis and Cell cycle. J. Nat. Prod. 61, 485-487.
Kuo, K.W.*, Yang, P.Y., Huang, Y.S. and Shieh, D.Z. （1998） Variations of the Gene Expression and Genomic Stability of Human Hepatoma Cells Integrated by Hepatitis B Virus DNA. Biochem. Mol. Biol. Int. 44, 1133-1140.
Chang, L.C., Tsai, T.R., Wang, J.J., Lin, C.N. and Kuo, K.W.* （1998） The Rhamnose Moiety of Solamargine Plays a Crucial role in Triggering Cell Death by Apoptosis. Biochem. Biophys. Res. Commun. 242, 21-25.
Kuo, K.W.*, Leung, M. and Leung, W.C. （1997） Intrinsic RNA Secondary Structure of Human TNFR-I Influences the Determination of Gene Expression by RT-PCR. Mol. Cell. Biochem. 177, 1-6.
Kuo, K.W* （1997） Role of the Exon 6 of Human PDGF A-chain mRNA in the Determination of the Gene Expression by Reverse Transcription-Polymerase Chain Reaction. Kaohsiung）. Med. Sci. 13, 59-66.
Hsu, S.H., Tsai, T.R., Lin, C.N., Yen, M.H. and Kuo, K.W. （1996） Solamagine purified from Solanum incanum Chinese Herb Triggers Gene Expression of Human TNFRI Which May Lead to Cell Apoptosis. Biochem. Biophys. Res. Commun. 229, 1-5.
Sheu, H.M., Leung, M., Leung, W.C. and Kuo, K.W.* （1996） In Vitro Amplification of Human Basic Fibroblast Growth Factor mRNA by RNA-Specific Exon-Junction Primers. Biochem. Mol. Biol. Int. 40, 907-914.
Kuo, K.W.*, Leung, M. and Leung, W.C. （1996） Identification and Characterization of A RNA Specific Primer for Human Tumor Necrosis Factor Receptor I （TNFR-I）. Biochem. Mol. Biol. Int. 40, 119-125.
Kuo, K.W.*, Yen, H.W., Chu, DJ. and Yeh, Y.C. （1991） Separation and Microanalysis of Growth Factors by Phast System Gel Electrophoresis and by DNA Synthesis in Cell Culture. J. Chromatogra. 543, 463-470.
蛋白質之活性基因工程
Liu, L.F., Chang, C.C., Liau, M.Y. and Kuo, K.W.* （1998） Genetic Characteri-zation of the mRNAs Encodinga-Bungarotoxin - Isoform and RNA editing in Bungarus multicinctus gland cells. Nucleic Acids Res. 26, 5624-5629.
Lin, S.R., Chi, S.H., Chang, L.S., Kuo, K.W. and Chang, C.C. （1996） Chemical Modification of Cationic Residues in Toxin a from the King Cobra （Ophiophagus hannah） Venom. J. Protein Chem. 15, 95-101.
Kuo, K.W.*, Chen, Y.C. and Chang, C.C. （1995） CDNA Sequence Analysis and Expression of -Bungarotoxin from Taiwan Banded Krait （Bungarus multicinctus）. Biochem. Biophys. Res. Commun. 216, 1088-1094.
Kuo, K.W.*, Chang, L.S. and Chang, C.C. （1995） Role of Amino and Carboxyl Groups of Cobrotoxin in the Conformational Stability and the Interaction with Acetylcholine Receptor. Int. J. Peptide Protein Res. 46, 181-185.
Kuo, K.W.*, Chang, L.S. and Chang, C.C. （1995） The Structural Loop II of Cobrotoxin is the Main Binding Region for nACHR and Epitope in the Region is ConformationDependent. J. Biochem. 117, 438-442.
Kuo, K.W.*, Chang, L.S. and Chang, C.C. （1995） Determination of Soluble naChRBinding Activity of a-Neurotoxins by an Innovative Precipitation with DEAESephacel. J. Biochem. 117, 1192-1195.
Chang, L.S., Kuo, K.W., Lin, J., Lin, S.R. and Chang, C.C. （1995） Analysis of ConformationIndependent Epitope and Conformational Epitope in Protein： A Study of Cobrotoxin from Taiwan Cobra Venom. J. Biochem. 117, 863-868.
Chang, L.S., Lin, J., Kuo, K.W., Lin, S.R. and Chang, C.C. （1995） Characterization of Epitopes in Native and Unfolded Cobrotoxin： Evidence of an Immunodominant C-terminal Region Related to the Production of Precipitating and Non-Precipitating Antibodies against Cobrotoxin. J. Biochem. 118, 686-692.
Chang, C.C., Lin, P.M., Chang, L.S. and Kuo, K.W.* （1995） Chemical Modification of Tryptophan Residues in a-Neurotoxins from Ophiophagus hannah （King Cobra） Venom. J. Protein Chem. 14, 89-94.
Lin, S.R., Chi, S.H., Chang, L.S., Kuo, K.W. and Chang, C.C. （1995） Chemical Modification of Cationic Groups of a Novel a-Neurotoxin （Oh-4） from King Cobra （Ophiophagus hannah） Venom. J. Biochem. 118, 297-301.
Kuo, K.W*., Chang, L.S., Lin, P.M., Leaber. R.J. and Chang, C.C. （1994） Immunological Neutralization of Cobrotoxin by Its Homologous Precipitin and Non-Precipitin Antibodies. J. Biochem. 116, 1227-1232.
Chang, L.S., Kuo, K.W. and Chang, C.C. （1994） Functional Involvement of Lys-6 in the Enzymatic Activity of Phospholipase A2 from Bungarus multicinctus （Taiwan Banded Krait）Snake Venom. J. Protein Chem. 13, 641-648.
Chang, L.S., Kuo, K.W. and Chang, C.C. （1993） Status of Tryptophan Residue in Cobrotoxin and a-Bungarotoxin. Biochem. Mol. Biol. Int. 29, 435-442.
Chang, C.C., Huang, T.Y., Kuo, K.W., Chen, S.W., Huang, K.F. and Chiou, S.H. （1993） Sequence Characterization of A Novel a-Neurotoxin from the King Cobra （Ophiophagus hannah） Venom. Biochem. Biophys. Res. Commun. 191, 214-223.
Chang, L.S., Kuo, K.W. and Chang, C.C. （1993） Identification of Functional Involvement of Tryptophan Residues in Phospholipase A2 from Naja naja atra （Taiwan Cobra） Snake Venom. Biochim. Biophys. Acta 1202, 216-220.
Kuo, K.W*. and Chang, C.C. （1992） Roles of the Aromatic Residues of Cobrotoxin in Antigenicity and Binding Activity to Nicotinic Acetylcholine Receptor. Biochem. Int. 27, 397-406.
Chang, C.C., Huang, T.Y., Kuo, K.W. and Chiou, S.H. （1992） Purification and Sequence Characterization of various a-Neurotoxins from the King Cobra （Ophiophagus hannah） Venom. J. Protein Chem. 11, 403-404.
Kou, K.W.* and Chang, C.C. （1991） High Affinity Antibody to Cobrotoxin Prepared from the Derivatived of Glutaraldehyde-Detoxified Cobrotoxin. J. Biochem. 110, 863-867.
Kuo, K.W.+ and Chang, C.C. （1990） Immunochemical Characterization of a-Bungarotoxin Detoxified with Glutaraldehyde. Kaohsiung J. Med. Sci. 6, 408-417.
Kuo, K.W* and Chang, C.C. （1986） Purification and Characterization of Hemorrhagic Toxins from the Venom of Trimeresurus mucrosquamatus. Kaohsiung J. Med. Sci. 2, 722-731.
Chang, C.C., Chen, C.C. and Kuo, K.W. （1985） Immunochemical Characterization of Cobrotoxin Modified with Glutaraldehyde. Kaohsiung J. Med. Sci. 1, 2-11.